what we've Learned about PPID — Equine Cushing’s Disease

PPID (Pituitary Pars Intermedia Dysfunction), commonly called Equine Cushing’s Disease, is a hormonal disorder involving the pituitary gland. It is most commonly seen in older horses and ponies, although early signs can develop before the classic symptoms become obvious.

🐴 A long, curly coat isn't the only sign.
One of the most recognizable signs of PPID is a long or unusually thick hair coat that doesn't shed normally. But earlier signs can be much more subtle.

🐴 Watch for changes in the topline.
PPID can cause muscle loss, especially along the topline, even when a horse still has a round belly or areas of fat. A horse can look "well-fed" while actually losing important muscle.

🐴 PPID can affect the immune system.
Horses with PPID may be more susceptible to infections, hoof abscesses and other health problems. Slow healing or recurring infections may be a reason to talk with your veterinarian.

🐴 Laminitis is an important warning sign.
Many horses with PPID also have insulin dysregulation. When insulin dysregulation is present, the risk of laminitis increases significantly. A horse with PPID should be evaluated for insulin problems, particularly if there is a history of laminitis.

🐴 Other signs can include:
• Delayed or abnormal shedding
• Excessive sweating
• Increased drinking and urination
• Loss of muscle or topline
• A pot-bellied appearance
• Fat deposits around the eyes, neck or tailhead
• Lethargy or decreased performance
• Recurrent infections or hoof abscesses
• Laminitis

🐴 PPID can be tested for.
Veterinarians commonly use blood testing, including ACTH testing, to help diagnose PPID. A TRH stimulation test may also be recommended, particularly when early PPID is suspected.

🐴 PPID can be managed.
There is currently no cure for PPID, but many horses can be successfully managed for years. Pergolide is commonly used to control the disease, along with appropriate nutrition, regular veterinary care, dental care and farrier care.

PPID doesn't always announce itself with a dramatically long, curly coat. Changes in shedding, topline, energy level, hoof health or susceptibility to infections can appear earlier.

Knowing what is normal for your horse makes it easier to recognize when something starts to change.

This information is shared from our experiences and lessons learned and is intended for educational purposes only. It is not a substitute for veterinary diagnosis or treatment. If you suspect your horse or pony may have PPID, talk with your veterinarian.